Denali Therapeutics

About Denali

Denali Therapeutics Inc. is a biotechnology company focused on neuroscience and based in South San Francisco, CA.

Our goal is to discover, develop and deliver therapeutics to defeat neurodegeneration, which is one of the most significant unmet medical needs of our time. There are limited effective therapeutic options available for patients with diseases like Alzheimer’s, Parkinson’s, ALS and Hunter Syndrome.  Recent genetic insights are revealing the underlying biology of neurodegeneration and potential drug targets, while enabling better patient selection, similar to how genetic insights have transformed the field of oncology, so we believe the time is right for breakthroughs. 

Our scientific strategy is guided by three overarching principles that we believe will significantly increase the probability of success: (1) Genetic Pathway Potential - We select our therapeutic targets and disease pathways based on studies that link human genetic variation to the risk of developing a neurodegenerative disease. (2) Engineering Brain Delivery - We engineer our product candidates to cross the blood-brain barrier ("BBB"), and act directly in the brain. (3) Biomarker-Driven Development - We discover, develop and utilize biomarkers to select the right patient population.

Collaborations are central to our strategy to develop our portfolio of product candidates. We have arrangements with biopharmaceutical companies, technology companies, academic institutions, foundations, and patient-focused data companies. Notable active arrangements include those with Biogen, Takeda, Sanofi, Harvard and the Michael J. Fox Foundation.

Denali got its start in May of 2015, and in six short years, we have built a diversified portfolio with five clinical programs and more than fifteen programs in the preclinical development stage. We envision our future as a fully integrated global organization serving patients. As of December 31, 2020, we had $1.5 billion in cash, cash equivalents and marketable securities. We believe that our existing cash will help us execute on growing our company and our portfolio. As we build and grow our capabilities, we maintain a deep focus on science at the core of our efforts to discover, develop and deliver medicines.

Denali Therapeutics South San Francisco, CA, USA
Apr 27, 2021
Full time
Corporate Counsel Denali Therapeutics is dedicated to developing and delivering breakthrough therapies for patients with neurodegenerative diseases through our rigorous, data-driven approach to translational medicine and clinical development.  Our approach is supported by strategic business principles that include a broad portfolio of diverse therapeutic modalities, parallel investments, and leveraging global collaborations. The Opportunity Denali Therapeutics is recruiting an experienced   Corporate Counsel , title to be commensurate with experience, reporting to the Senior Vice President, Associate General Counsel and Head of Legal. You will join and work closely with multiple teams across the business to help build, operate and defend Denali’s corporate legal affairs.  We have built a Legal team that is fully integrated across Denali’s business, and we need your help to develop and implement corporate legal strategies. Denali is a rapidly growing, public company...