D. E. Shaw Research is an independent research group that is pursuing an ambitious, long-term strategy aimed at fundamentally transforming the process of drug discovery. We have developed a special-purpose supercomputer, ANTON®, capable of executing molecular dynamics (MD) simulations orders of magnitude faster than was previously possible. Our current projects include investigations of proteins and other biomedically relevant macromolecules as well as the development of computational chemistry methods to enable more accurate and effective MD simulations.